• 文章类型: Journal Article
    目的:本研究比较了两种假体材料的听力结果,骨和钛,用于骨成形术。
    方法:这项基于全国注册的回顾性研究使用了由瑞典耳手术质量注册中心(SwedEar)收集的系统数据。
    方法:数据来自瑞典进行骨成形术的诊所。
    方法:在2013年至2019年期间,在SwedEar注册了使用骨或钛假体进行骨成形术的患者。
    方法:听力结果表示为空气-骨间隙(ABG)增益。
    结果:研究发现,对于部分听骨置换假体(PORP)或全听骨置换假体(TORP),ABG或空气传导(AC)的骨和钛之间没有差异。在ABG和AC结果的PORP和TORP之间的比较中,无论使用何种材料,PORP显示了一个小优势,额外提高了3.3dB(95%CI[置信区间],在ABG中为0.1-4.4),在AC中为2.2dB(95%CI,1.7-4.8)。在使用TORP的二次手术中,钛产生的高频纯音平均略好的结果。成功率,a术后ABG≤20dB,在整个集团62%的运营中实现了目标。
    结论:用于重建听骨链的骨和钛对于PORP和TORP手术均产生相似的听力结果。然而,钛可能是涉及TORP的二次手术的首选。成功率,a术后ABG≤20dB,与其他研究一致,但患者选择标准和手术技术仍有改进的空间。
    OBJECTIVE: This study compares hearing outcomes of two prosthesis materials, bone and titanium, used in ossiculoplasty.
    METHODS: This retrospective nationwide registry-based study uses data systematically collected by the Swedish Quality Registry for Ear Surgery (SwedEar).
    METHODS: The data were obtained from clinics in Sweden that perform ossiculoplasty.
    METHODS: Patients who underwent ossiculoplasty using either bone or titanium prostheses were registered in SwedEar between 2013 and 2019.
    METHODS: Hearing outcome expressed as air-bone gap (ABG) gain.
    RESULTS: The study found no differences between bone and titanium for ABG or air conduction (AC) for either partial ossicular replacement prostheses (PORP) or total ossicular replacement prostheses (TORP). In a comparison between PORP and TORP for ABG and AC outcomes, regardless of the material used, PORP showed a small advantage, with an additional improvement of 3.3 dB (95% CI [confidence interval], 0.1-4.4) in ABG and 2.2 dB (95% CI, 1.7-4.8) in AC. In secondary surgery using TORP, titanium produced slightly better results for high-frequency pure tone average. The success rate, a postoperative ABG ≤20 dB, was achieved in 62% of the operations for the whole group.
    CONCLUSIONS: Both bone and titanium used to reconstruct the ossicular chain produce similar hearing outcomes for both PORP and TORP procedures. However, titanium may be a preferable option for secondary surgeries involving TORP. The success rate, a postoperative ABG ≤20 dB, is consistent with other studies, but there is room for improvement in patient selection criteria and surgical techniques.
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  • 文章类型: Journal Article
    近年来,智能手机和其他无线技术在医疗保健中的使用发展迅速。然而,在某些情况下,尤其是儿科医疗问题,移动医疗技术获取信息的可靠性仍然存在争议。本文的主要目的是评估智能手机应用程序在儿科医疗条件的检测和诊断中的相关性,其中已经开发了最多的应用程序。这是为诊断急性中耳炎而开发的智能手机应用程序的情况,渗出性中耳炎,听力障碍,肥胖,弱视,和视力筛查。在某些情况下,这些应用程序提供的信息显着提高了医生的诊断能力。然而,区分有效的应用程序和可能导致错误的应用程序可能非常困难。这凸显了在日常临床实践中包括基于智能手机的人工智能之前仔细选择应用程序的重要性。
    In recent years, the use of smartphones and other wireless technology in medical care has developed rapidly. However, in some cases, especially for pediatric medical problems, the reliability of information accessed by mobile health technology remains debatable. The main aim of this paper is to evaluate the relevance of smartphone applications in the detection and diagnosis of pediatric medical conditions for which the greatest number of applications have been developed. This is the case of smartphone applications developed for the diagnosis of acute otitis media, otitis media with effusion, hearing impairment, obesity, amblyopia, and vision screening. In some cases, the information given by these applications has significantly improved the diagnostic ability of physicians. However, distinguishing between applications that can be effective and those that may lead to mistakes can be very difficult. This highlights the importance of a careful application selection before including smartphone-based artificial intelligence in everyday clinical practice.
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  • 文章类型: Journal Article
    Over the past 2 decades, the increasing availability of computed tomography (CT) and magnetic resonance imaging (MRI) as well as the growing professional expertise have significantly improved the diagnostics of middle and inner ear diseases in dogs and cats. In answering some of the diagnostic questions, CT and MRT demonstrate equivalent performance. For most questions, however, there are differences in the diagnostic performance due to the physical imaging properties of the 2 modalities.CT is more sensitive in demonstrating involvement of the bulla wall and is more effective for detecting abnormal content within the tympanic bulla. In addition, with CT it is often easier to guide tissue samplings. On the other hand, structural changes of the soft tissues of the skull, head, meninges, brain, and nerves are not or only insufficiently detectable on CT images. MRI is clearly superior here. Therefore, MRI is essential for the characterization of materials inside the bulla cavity and for demonstrating the extent of any central spread of otitis media (OM).In this image essay, CT and MRI features of OM and resulting secondary lesions described in the literature are analyzed and summarized. Own image examples are used for illustration. Information on the etiology, pathogenesis, pathomorphology, and clinical signs important for understanding these changes are presented in concise descriptions.
    Über die letzten 2 Jahrzehnte haben die zunehmende Verfügbarkeit von Computertomografen (CT) und Magnetresonanztomografen (MRT) sowie die gewachsene fachliche Expertise die Diagnostik von Mittel- und Innenohrerkrankungen bei Hunden und Katzen erheblich verbessert. Bei der Beantwortung von einer Reihe diagnostischer Fragestellungen können CT und MRT als gleichwertige Verfahren angesehen werden. Bei anderen Fragestellungen wiederum bestehen Unterschiede in der diagnostischen Leistungsfähigkeit aufgrund der physikalischen Abbildungseigenschaften. Sensitiver ist die CT bei der Darstellung von Veränderungen der Bullawand. Die CT ist auch das effektivere Verfahren, wenn abnormaler Inhalt in der Bulla tympanica nachgewiesen werden soll. Darüber hinaus ist es mit der CT oft einfacher, die Entnahme von Gewebeproben zu planen und durchzuführen. Andererseits sind strukturelle Veränderungen der Weichteile des Kopfes, der Meningen, des Gehirns und von Nerven in der CT nicht oder nur unzureichend erkennbar. Hier ist die MRT klar überlegen. Daher ist die MRT für die Typisierung von Materialen in der Bulla sowie die Darstellung des Ausmaßes einer eventuell existierenden zentralen Ausbreitung einer Otitis media (OM) unerlässlich.In diesem Bildessay werden die in der Literatur beschriebenen bildmorphologischen Merkmale einer OM und die durch sie bedingten sekundären Pathologien analysiert und zusammengefasst. Eigene Bildbeispiele dienen der Illustration. Für das Verständnis der Veränderungen wichtige Informationen zur Ätiologie, Pathogenese, Pathomorphologie und dem klinischen Erscheinungsbild werden in kurzer Form dargestellt.
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  • 文章类型: Journal Article
    OBJECTIVE: To describe secondary secretory otitis media (SSOM) due to obstruction of the nasopharyngeal opening of the auditory tube in cats and dogs and to characterize the effusion by macroscopic description, microscopic cytology and bacteriological analysis.
    METHODS: Three cats and 2 dogs with middle ear effusion and obstruction of the nasopharyngeal opening of the auditory tube detected on CT scans received myringotomy followed by macroscopic description, microscopic cytology and bacteriological analysis of the fluid obtained.
    RESULTS: All animals had serous to mucoid middle ear effusions and, in 2 cases, large numbers of inflammatory cells and secondary infection. Causes of auditory tube dysfunction ranged from iatrogenic stents (2) to neoplasia (3). In the non-neoplastic cases, effusion resolved in all cases after removal of the underlying cause.
    CONCLUSIONS: Obstruction of the nasopharyngeal opening of the auditory tube leads to accumulation of fluid within the middle ear in cats and dogs. If the cause of obstruction can be removed, fluid accumulation resolves. Fluid characteristics are comparable to middle ear effusions in pugs and French bulldogs. It is important to always examine the nasopharynx in cases of middle ear effusion to rule out SSOM.
    UNASSIGNED: Eine sekretorische Otitis media mit Paukenhöhlenerguss kann durch Obstruktionen der pharyngealen Öffnung der Eustachischen Röhre ausgelöst werden. Ziel dieser Arbeit war die makroskopische Beschreibung des Ergusses bei Katzen und Hunden sowie die mikroskopische und bakteriologische Analyse.
    METHODS: Drei Katzen und 2 Hunde mit Paukenhöhlenergüssen und einer in der Computertomografie detektierten Obstruktion der nasopharyngealen Öffnung der Eustachischen Röhre wurden in die Studie eingeschlossen. Das per Myringotomie gewonnene Sekret wurde makroskopisch, zytologisch und bakteriologisch untersucht.
    UNASSIGNED: In allen Fällen war das Sekret serös bis mukös. In 2 Fällen wurde eine hohe Anzahl an Entzündungszellen mit einer sekundären Infektion nachgewiesen. Ursachen für die Obstruktion der Eustachischen Röhre reichten von iatrogen durch einen nasopharyngealen Stent (2) bis zu Neoplasie (3). In allen nicht-neopastischen Fällen waren die Paukenhöhlenergüsse nach Entfernung der auslösenden Obstruktion reversibel.
    UNASSIGNED: Eine Obstruktion der nasopharyngealen Öffnung der Eustachischen Röhre führt zu einem Flüssigkeitserguss im Mittelohr bei Hunden und Katzen. Wenn die Obstruktion behoben werden kann, sind diese Ergüsse reversibel. Analysen der Ergüsse gleichen denen bei brachyzephalen Hunden. Im Falle eines Paukenhöhlenergusses sollte immer auch der Nasopharynx untersucht werden, um eine sekundäre sekretorische Otitis media auszuschließen.
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  • 文章类型: Journal Article
    背景:目前的指南建议,对于患有急性中耳炎(AOM)和耳部分泌物的儿童,可以考虑口服抗生素,但缺乏关于抗生素-皮质类固醇滴耳剂相对有效性的证据.
    目的:确定在患有AOM和耳部分泌物的儿童中,抗生素-皮质类固醇滴耳剂是否不劣于口服抗生素。
    方法:在荷兰初级保健中设置的开放随机对照非劣效性试验。
    方法:儿童随机接受氢化可的松-杆菌肽-粘菌素滴耳剂(五滴,每天三次在排出的耳朵中)或阿莫西林悬浮液(每天每公斤体重50毫克,分三次口服给药)7天。主要结果是在第3天耳痛和发烧消退的儿童比例。
    结果:在2017年12月至2023年3月之间,由于各种原因,计划中的350名儿童中有58名由于累积缓慢而被招募。与接受口服抗生素治疗的儿童(n=31)相比,接受耳塞治疗的儿童(n=26)在3天的耳痛和发烧缓解率较低:42%vs65%;调整后的风险差异20.3%,95%置信区间-5.3%至41.9%),父母报告的耳朵放电时间更长(6天vs3天;P=.04),1-3天的平均耳痛评分(Likert量表0-6)略高(2.1vs1.4,P=.02),但在3个月内接受的口服抗生素疗程较少(25名儿童11例,30名儿童33例),胃肠道不适和皮疹较少(12%vs32%,8%vs16%,分别)。
    结论:早期终止治疗使我们无法确定抗生素-皮质类固醇滴耳剂的非劣效性。我们有限的数据,需要确认,建议口服抗生素可能比抗生素-皮质类固醇滴耳剂更有效地缓解症状并缩短耳部分泌物的持续时间。
    BACKGROUND: Current guidance suggests oral antibiotics can be considered for children with acute otitis media (AOM) and ear discharge, but there is an absence of evidence regarding the relative effectiveness of antibiotic-corticosteroid eardrops.
    OBJECTIVE: To establish whether antibiotic-corticosteroid eardrops are non-inferior to oral antibiotics in children with AOM and ear discharge.
    METHODS: Open randomized controlled non-inferiority trial set in Dutch primary care.
    METHODS: Children were randomized to hydrocortisone-bacitracin-colistin eardrops (five drops, three times per day in the discharging ear(s)) or amoxicillin suspension (50 mg per kilogram of body weight per day, divided over three doses administered orally) for 7 days. The primary outcome was the proportion of children with resolution of ear pain and fever at day 3.
    RESULTS: Between December 2017 and March 2023, 58 of the planned 350 children were recruited due to slow accrual for various reasons. Children assigned to eardrops (n = 26) had lower resolution rates of ear pain and fever at 3 days compared to those receiving oral antibiotics (n = 31): 42% vs 65%; adjusted risk difference 20.3%, 95% confidence interval -5.3% to 41.9%), longer parent-reported ear discharge (6 vs 3 days; P = .04), and slightly higher mean ear pain scores (Likert scale 0-6) over days 1-3 (2.1 vs 1.4, P = .02), but received fewer oral antibiotic courses in 3months (11 for 25 children vs 33 for 30 children), and had less GI upset and rash (12% vs 32% and 8% vs 16%, respectively).
    CONCLUSIONS: Early termination stopped us from determining non-inferiority of antibiotic-corticosteroid eardrops. Our limited data, requiring confirmation, suggest that oral antibiotics may be more effective than antibiotic-corticosteroid eardrops in resolving symptoms and shortening the duration of ear discharge.
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  • 文章类型: Journal Article
    目的:新生儿听力筛查(UNHS)后,与渗出性中耳炎(OME)相关的传导性听力损失(CHL)的新生儿转诊率增加,情感,和财政负担。本研究分析了长期、听力学,以及与新生儿OME相关的CHL的医学特征,以便在技术驱动的UNHS检测和转诊率提高后建立标准化方案。
    方法:在2013年1月1日至2021年12月31日期间,对所有患有OME相关CHL的新生儿进行了回顾性研究,这些新生儿在2013年1月1日和2021年12月31日期间使用MAICO设备进行了UNHS失败后转诊到鲁汶大学医院(比利时)。后续协商,听觉测试,转诊方,出生月份,听力损失程度,潜在的病理和危险因素,正常化的时间,对通风管的需求进行了评估。
    结果:与OME相关的CHL的发生率在2013年至2021年之间稳定。在所有转诊的OME婴儿中,52.3%显示自发恢复。与没有先天性疾病的儿童相比,患有先天性疾病的儿童达到听力正常化的平均时间明显更长。此外,这些儿童中有74.4%接受了通风管,而没有潜在病理的儿童则为32.0%。OME相关CHL的发生率与听力损失程度无相关性,入院新生儿重症监护,或者鼻饲管的病史。
    结论:在因OME而导致UNHS失败的儿童中,2/3无基础疾病的婴儿在一年内无需手术干预即可自发恢复听力。在患有潜在先天性疾病的儿童中,听力恢复的时间更长,手术干预的风险更高,强调需要实施UNHS标准化协议。
    OBJECTIVE: Increased neonatal referral rate of conductive hearing loss (CHL) related to otitis media with effusion (OME) following universal neonatal hearing screening (UNHS) may cause an unnecessary clinical, emotional, and financial burden. This study analyzes the long-term, audiological, and medical characteristics of CHL associated with OME in neonates in order to establish a standardized protocol following technology-driven improvements in detection and referral rates in UNHS.
    METHODS: A retrospective study of all neonates with OME-related CHL referred to the University Hospital of Leuven (Belgium) after failing UNHS with the MAICO devices between January 1, 2013 and December 31, 2021 was performed. Follow-up consultations, auditory tests, referral side, birth month, hearing loss degree, underlying pathologies and risk factors, time to normalization, and need for ventilation tubes were assessed.
    RESULTS: The incidence of CHL related to OME was stable between 2013 and 2021. Of all referred infants with OME, 52.3 % demonstrated spontaneous recovery. The average time to hearing normalization was significantly longer in children with underlying congenital pathologies compared to those without. Moreover, 74.4 % of these children received ventilation tubes compared to 32.0 % of children without underlying pathologies. No correlation was found between the incidence of OME-related CHL with either a hearing loss degree, admission to neonatal intensive care, or history of a nasogastric feeding tube.
    CONCLUSIONS: In children who failed UNHS due to OME, hearing recovers spontaneously without surgical intervention in 2/3 of the infants without underlying conditions within one year. In children with underlying congenital disorders, the time to hearing recovery is longer and the risk for surgical intervention is higher, underlining the need for implementing a UNHS standardized protocol.
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  • 文章类型: Journal Article
    Myhre综合征(MS)是一种罕见的遗传病,表现为多种遗传异常,包括唇腭裂和咽鼓管功能障碍。这些患者由于插管和粘膜炎症而存在气道瘢痕形成的高风险。听力损失(传导性或混合性,不同严重程度)是这些患者的常见合并症,其确切病因尚不清楚。我们介绍了2例无关的MS儿童,他们因纤维化和中耳间隙闭塞而遭受进行性混合性听力损失。两名患者都有多组耳管,表现出早期挤压。年龄较大的患者在11岁时接受了骨传导植入,从而大大提高了语音识别和交互技能。另一名年轻患者表现出类似的轨迹,但尚未进行植入。耳鼻喉科医师应采取谨慎的方法对耳膜和中耳进行手术,以避免该易感患者人群中不必要的纤维化诱导。这些病例突出了新描述的听力损失的病因,并暗示了骨传导植入的益处。
    Myhre syndrome (MS) is a rare genetic condition that presents with multiple genetic anomalies including cleft lip and palate and Eustachian tube dysfunction. These patients are at a high risk for airway scarring from intubation and mucosal inflammation. Hearing loss (conductive or mixed, of varying severity) is a common comorbidity in these patients, the exact etiology of which is still unclear. We present the cases of 2 unrelated children with MS who suffered progressive mixed hearing loss from fibrosis and obliteration of the middle ear spaces. Both patients had multiple sets of ear tubes that demonstrated early extrusion. The older patient underwent bone conduction implantation at age 11 which resulted in dramatic improvement of speech recognition and interactive skills. The other younger patient demonstrates a similar trajectory but has not yet undergone implantation. Otolaryngologists should take a cautious approach to surgery of the eardrum and middle ear to avoid unnecessary induction of fibrosis in this susceptible patient population. These cases highlight a newly described etiology for hearing loss and suggest a benefit to bone conduction implantation.
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  • 文章类型: Case Reports
    背景:噬血细胞性淋巴组织细胞增生症(HLH)是一种可能危及生命的综合征,早期识别和治疗对于改善预后至关重要。HLH的特点是不受控制的免疫激活导致发烧,血细胞减少,肝脾肿大,凝血异常,和升高的典型标记。这种情况可以是遗传的或继发性的,后者通常由感染引发。这里,我们介绍了急性中耳炎(AOM)继发HLH的独特病例,常见的耳部感染.
    方法:我们描述了一个4岁男孩,他最初表现为高烧和耳痛,后来诊断为双侧AOM。尽管有抗生素治疗,他的病情恶化。
    方法:患者符合HLH诊断标准。
    方法:使用免疫球蛋白联合治疗的积极治疗,静脉注射类固醇(地塞米松),环孢菌素,并进行依托泊苷。
    结果:治疗1个月后,观察到耳科症状的改善,血液学检查结果逐渐好转并恢复正常。
    结论:AOM和HLH之间的联系可能与炎症反应和免疫机制有关,强调在严重感染病例中考虑HLH的重要性。这种情况强调需要及时诊断和管理,尤其是在继发性HLH情况下,改善患者预后。必须意识到这两个条件之间的潜在相关性,医疗保健专业人员应该考虑HLH的可能性。
    BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening syndrome for which early recognition and treatment are essential for improving outcomes. HLH is characterized by uncontrolled immune activation leading to fever, cytopenias, hepatosplenomegaly, coagulation abnormalities, and elevated typical markers. This condition can be genetic or secondary, with the latter often triggered by infections. Here, we present a unique case of HLH secondary to acute otitis media (AOM), a common ear infection.
    METHODS: We describe a 4-year-old boy who initially presented with a high fever and otalgia, later diagnosed with bilateral AOM. Despite antibiotic treatment, his condition deteriorated.
    METHODS: The patient fulfilled diagnostic criteria for HLH.
    METHODS: Aggressive treatment by using combination therapy with immunoglobulins, intravenous steroids (dexamethasone), cyclosporine, and etoposide was performed.
    RESULTS: After 1 month of treatment, improvement in the otologic symptoms was observed, and hematological findings gradually improved and normalized.
    CONCLUSIONS: The link between AOM and HLH may be associated with inflammatory responses and immunological mechanisms, highlighting the importance of considering HLH in severe infection cases. This case emphasizes the need for prompt diagnosis and management, especially in secondary HLH scenarios, to improve patient outcomes. It is imperative to be aware of the potential correlation between these 2 conditions, and healthcare professionals should consider the likelihood of HLH.
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  • 文章类型: Journal Article
    背景:中耳炎(OM)是一种常见的临床耳部疾病。噪声严重损害人的听力功能。本研究旨在研究各种噪声类型对轻度OM康复患者听力功能的影响。
    方法:回顾性选择2020年5月至2023年5月在我院接受治疗的160例轻度OM患者进行本研究。根据临床数据,将患者分为非噪声组(n=80)和噪声组(n=80)。在500、1000和2000Hz的各种噪声类型中比较了两组的听力阈值。此外,在相同条件下比较噪声组的听力阈值。
    结果:噪声组在500、1000和2000Hz的听阈明显高于非噪声组(P<0.05)。在交通状况下,城市建设,和工业噪音,噪声组的500、1000和2000Hz的听觉阈值明显高于家庭和语音噪声下的听觉阈值(P<0.05)。
    结论:噪声与OM患者的听力功能密切相关。交通,城市建设,和工业噪声极大地影响了从轻度OM恢复的患者的听力功能。
    BACKGROUND: Otitis media (OM) refers to a common clinical ear disease. Noise seriously damages human hearing function. This study aimed to investigate the effects of various noise types on the hearing function of patients who have recovered from mild OM.
    METHODS: A total of 160 patients with mild OM treated at our hospital from May 2020 to May 2023 were retrospectively selected for this study. Based on clinical data, the patients were divided into the non-noise group (n = 80) and the noise (n = 80) group. The hearing thresholds of the two groups were compared across various noise types at 500, 1000, and 2000 Hz. In addition, the hearing thresholds of the noise group were compared under the same conditions.
    RESULTS: The noise group exhibited significantly higher hearing thresholds at 500, 1000, and 2000 Hz than the non-noise group (P < 0.05). Under traffic, urban construction, and industrial noises, the auditory thresholds at 500, 1000, and 2000 Hz in the noise group were significantly higher than those observed under domestic and speech noises (P < 0.05).
    CONCLUSIONS: Noise shows a close relationship with the hearing function of patients with OM. Traffic, urban construction, and industrial noises greatly influence the hearing function of patients who have recovered from mild OM.
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  • 文章类型: Case Reports
    急性化脓性中耳炎偶尔会导致面瘫,这需要及时诊断和治疗。面瘫,贝尔麻痹的同义词,是导致面部肌肉一侧快速减弱的一种情况,导致那一边的脸下垂。决定病情进程的主要因素是通过物理治疗进行康复。这里,我们介绍了一名26岁女性的病例,她在2024年2月21日左耳感到不适,但当时选择忽略.她观察到嘴里突然出现偏差,并参观了一家乡村医院,她被录取的地方.在检查过程中观察到面部不对称,她被发现在House-Brackmann量表上有V级.通过哑剧治疗开始了接近正常的肌肉动作,通过面部本体感觉神经肌肉促进和电刺激给予本体感觉刺激。所有这些方法都以显著的方式使患者受益。
    Acute suppurative otitis media can occasionally result in facial paralysis, which calls for prompt diagnosis and treatment. Facial paralysis, a synonym for Bell\'s palsy, is a condition that causes rapid weakening of one side of the face muscles, leading to drooping of the face on that side. A major factor in determining the course of the condition is rehabilitation through physiotherapy. Here, we present a case of a 26-year-old female who felt discomfort in her left ear on February 21, 2024, but chose to ignore it then. She observed an abrupt deviation in her mouth and visited a rural hospital, where she was admitted. Facial asymmetry was observed during the examination, and she was found to have a grade V on the House-Brackmann scale. A near-normal muscle action was initiated by mime therapy, and proprioceptive stimulation was given by facial proprioceptive neuromuscular facilitation along with electrical stimulation. All these approaches benefited the patient in a significant manner.
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